Thermostable vaccine against PPR disease

Reliable, Effective, and Accessible Disease Control for Small Ruminants.

The solution is a homologous live attenuated vaccine that effectively guards small ruminants against Peste des Petits Ruminants (PPR). The vaccine is proven to remain stable at ambient temperatures for extended periods, even withstanding spikes of 38°C for 9 days and 40°C for 7 days.

This technology is TAAT1 validated.

8•7

Scaling readiness: idea maturity 8/9; level of use 7/9

Project adoption1

Technology integrated in the ENSURE project.

Project	Countries	Beneficiaries	Budget (USD) & duration	Key figures
ENSURE Enabling Environments for Sustainable Regional Agriculture Extension	Kenya Rwanda Burundi Democratic Republic of the Congo South Sudan Uganda Tanzania	Direct: 3,000,000	13.14 million 2024–2027	149,940 farmers trained 9,996 Training 2→3.5 tons/ha cereals production expected 350 agent trained

Project

Countries

Beneficiaries

Budget (USD) & duration

Key figures

ENSURE
Enabling Environments for Sustainable Regional Agriculture Extension

Kenya
Rwanda
Burundi
Democratic Republic of the Congo
South Sudan
Uganda
Tanzania

Direct: 3,000,000

13.14 million

2024–2027

149,940 farmers trained
9,996 Training
2→3.5 tons/ha cereals production expected
350 agent trained

Figures in italic are from project plans and may change during implementation.

See project details ›

Adults 18 and over: Positive high

Others: No impact

The poor: Positive low

Under 18: Positive low

Women: Positive medium

Climate adaptability: Highly adaptable

Farmer climate change readiness: Significant improvement

Biodiversity: Positive impact on biodiversity

Environmental health: Moderately improves environmental health

Water use: Same amount of water used

Problem

High disease burden: PPR can cause severe mortality among small ruminants and undermine livestock based livelihoods.
Limited access to vaccination: Farmers in areas with weak refrigeration infrastructure may have limited access to effective PPR vaccination.
Cold chain constraints: Maintaining appropriate vaccine temperatures can create logistical challenges in remote and underserved areas.
Limited vaccination coverage: Cold chain requirements can restrict the reach of disease control campaigns.
Risk of vaccine instability: Difficult storage and transportation conditions can threaten vaccine effectiveness.
Economic losses for vulnerable producers: PPR outbreaks can generate significant losses for small ruminant farmers who depend on livestock for income and livelihoods.
Challenges reaching dispersed populations: Livestock herds spread across large geographical areas can be difficult to vaccinate efficiently.
Need for integrated disease control: Effective PPR management requires vaccination alongside surveillance, movement monitoring, quarantine and biosecurity measures.

Solution

Accessible disease protection: The thermostable vaccine helps extend effective PPR vaccination to areas where cold storage infrastructure is limited.
Reduced logistical barriers: Temperature stability simplifies vaccine handling and distribution during appropriate periods.
Expanded vaccination coverage: Easier logistics can facilitate vaccination of more animals and reach underserved livestock populations.
Improved protection of vulnerable farmers: Effective vaccination helps reduce mortality and protect livestock assets.
Reduced economic losses: Preventing PPR outbreaks can help protect livestock based livelihoods from severe disease related losses.
Better suitability for remote areas: Thermostability provides greater flexibility for vaccination operations in areas with limited refrigeration.
Reliable vaccine performance: Field trials have demonstrated the vaccine's effectiveness in protecting small ruminants against PPR.
Integration with disease surveillance: Vaccination can be combined with outbreak reporting, animal movement monitoring, quarantine and biosecurity measures to strengthen disease control.

Key points to design your program

Thermostable Vaccine against PPR Disease is an innovative livestock health technology that protects sheep and goats against Peste des Petits Ruminants (PPR), reducing mortality, improving livestock productivity, and strengthening pastoral livelihoods through reliable vaccination without cold-chain dependence. The technology can be integrated into livestock development, animal health, food security, rural livelihood, and climate resilience programs to support sustainable disease control and improve livestock productivity. Its adoption contributes to SDGs 1 (No Poverty), 2 (Zero Hunger), 3 (Good Health and Well-being), 8 (Decent Work and Economic Growth), 9 (Industry, Innovation and Infrastructure), 12 (Responsible Consumption and Production), and 13 (Climate Action).

To integrate this technology into your project, plan and budget for the following activities and prerequisites:

Assess PPR prevalence, livestock production systems, vaccination coverage, and veterinary service capacity in target areas.
Establish partnerships with International Livestock Research Institute (ILRI), national veterinary services, veterinary authorities, and other livestock value chain stakeholders to support vaccine deployment and technology scaling.
Facilitate access to thermostable PPR vaccines, vaccination equipment, and last-mile delivery systems to ensure timely and widespread immunization.
Implement vaccination campaigns and training for veterinarians, animal health professionals, community animal health workers, livestock keepers, women's groups, and youth enterprises on vaccine handling, vaccination protocols, disease surveillance, and outbreak reporting.
Support extension and dissemination activities to promote routine vaccination and sustainable disease control.
Promote the participation of women, youth, and livestock keepers in animal health services and technology adoption activities.
Implement monitoring, learning, and inclusion activities throughout the project lifecycle.
Track key indicators such as vaccination coverage, PPR incidence, livestock mortality, farmer adoption, household income, and livestock productivity.

IP

Open source / open access

Scaling Readiness describes how complete a technology's development is and its ability to be scaled. It produces a score that measures a technology's readiness along two axes: the level of maturity of the idea itself, and the level to which the technology has been used so far.

Each axis goes from 0 to 9 where 9 is the “ready-to-scale” status. For each technology profile in the e-catalogs we have documented the scaling readiness status from evidence given by the technology providers. The e-catalogs only showcase technologies for which the scaling readiness score is at least 8 for maturity of the idea and 7 for the level of use.

The graph below represents visually the scaling readiness status for this technology, you can see the label of each level by hovering your mouse cursor on the number.

Scaling readiness score of this technology

Maturity of the idea 8 out of 9

Uncontrolled environment: tested

Level of use 7 out of 9

Common use by projects NOT connected to technology provider

Maturity of the idea										Level of use
9
8
7
6
5
4
3
2
1
	1	2	3	4	5	6	7	8	9

Project	Countries	Beneficiaries	Budget (USD) & duration	Key figures
ENSURE Enabling Environments for Sustainable Regional Agriculture Extension	Kenya Rwanda Burundi Democratic Republic of the Congo South Sudan Uganda Tanzania	Direct: 3,000,000	13.14 million 2024–2027	149,940 farmers trained 9,996 Training 2→3.5 tons/ha cereals production expected 350 agent trained

Project

Countries

Beneficiaries

Budget (USD) & duration

Key figures

ENSURE
Enabling Environments for Sustainable Regional Agriculture Extension

Kenya
Rwanda
Burundi
Democratic Republic of the Congo
South Sudan
Uganda
Tanzania

Direct: 3,000,000

13.14 million

2024–2027

149,940 farmers trained
9,996 Training
2→3.5 tons/ha cereals production expected
350 agent trained

Figures in italic are from project plans and may change during implementation.

Countries with a green colour: Tested & adopted
Countries with a bright green colour: Adopted
Countries with a yellow colour: Tested
Countries with a blue colour: Testing ongoing

Countries where the technology is being tested or has been tested and adopted
Country	Testing ongoing	Tested	Adopted
Mali	–No ongoing testing	Tested	Adopted

This technology can be used in the colored agro-ecological zones. Any zones shown in white are not suitable for this technology.

Agro-ecological zones where this technology can be used
AEZ	Subtropic - warm	Subtropic - cool	Tropic - warm	Tropic - cool
Arid
Semiarid
Subhumid
Humid

Source: HarvestChoice/IFPRI 2009

The United Nations Sustainable Development Goals that are applicable to this technology.

Goal 1: no poverty

Goal 2: zero hunger

Goal 3: good health and well-being

Goal 8: decent work and economic growth

Goal 9: industry, innovation and infrastructure

Goal 12: responsible production and consumption

Goal 13: climate action

Report outbreaks of PPR to national veterinary authorities as PPR is a notifiable disease.
Implement disease surveillance considering animal movement, farm quarantine, and identification of high-risk areas.
Source vaccines from reliable suppliers and ensure proper cold chain management.
Administer vaccines through trained and certified vaccinators, ensuring correct dosage.
Monitor vaccinated animals for signs of immunity and address any concerns promptly.

Last updated on Oct 1, 2026