Thermostable vaccine against PPR disease

Reliable, Effective, and Accessible Disease Control for Small Ruminants.

The solution is a homologous live attenuated vaccine that effectively guards small ruminants against Peste des Petits Ruminants (PPR). The vaccine is proven to remain stable at ambient temperatures for extended periods, even withstanding spikes of 38°C for 9 days and 40°C for 7 days.

This technology is TAAT1 validated.

8•7

Scaling readiness: idea maturity 8/9; level of use 7/9

Adults 18 and over: Positive high

Others: No impact

The poor: Positive low

Under 18: Positive low

Women: Positive medium

Climate adaptability: Highly adaptable

Farmer climate change readiness: Significant improvement

Biodiversity: Positive impact on biodiversity

Environmental health: Moderately improves environmental health

Water use: Same amount of water used

Problem

High Mortality Rates: PPR is a fast-spreading viral disease of sheep and goats with high mortality rates, especially among younger animals.
Limited Vaccine Storage: The requirement for cold storage has limited the widespread use of the current available vaccine within eradication programs.
Economic Losses: Economic losses from PPR across Africa and Asia are estimated to be USD 2.1 billion per year.
Vaccine Stability: Previous constraints included maintaining vaccine stability, especially in areas with limited access to cold storage.
Limited Coverage: The need for cold storage restricted the adequate coverage of vaccination campaigns, limiting the protection of animals.
Outbreak Reporting: PPR is a notifiable disease, necessitating the reporting of outbreaks to national veterinary authorities.
Disease Surveillance: Disease surveillance, including animal movement monitoring and quarantine measures, is crucial for controlling outbreaks and preventing spread.
Biosecurity Measures: Identification of high-risk areas with inadequate biosecurity measures is essential to prevent infection and spread.

Solution

Stability at Ambient Temperatures: Eliminates the need for cold storage for a given number of days, making the vaccine widely accessible and reducing logistical challenges.
Extended Shelf Life: Remains effective for up to one week at ambient temperatures, ensuring vaccines remain potent even in areas with limited refrigeration facilities.
Proven Effectiveness: Demonstrated efficacy during field trials, providing reliable protection against PPR in small ruminants.
Cost-Effective: Reduces storage costs associated with cold chain maintenance, making the vaccine a more affordable solution for farmers.
Improved Coverage: Enables vaccination of a larger number of animals in less time, contributing to more comprehensive disease control efforts.
Lifetime Immunity for Most Animals: Offers long-term protection, reducing mortality rates and economic losses associated with PPR outbreaks.
Compliance with Eradication Efforts: Aligns with international standards set by organizations like the World Organization for Animal Health and the Food and Agriculture Organization, supporting global efforts to eradicate PPR.

Key points to design your project

The technology reduces economic losses and poverty among small ruminant farmers by preventing PPR outbreaks and enhancing food security. It improves animal health, reduces disease spread, and fosters economic growth in the agricultural sector. Additionally, its innovation in vaccine technology promotes sustainability and contributes to climate action efforts.

To incorporate this technology into your project, the following steps and considerations are recommended:

Ensure the availability and affordability of thermostable vaccines for small ruminant producers.
Educate producers about the advantages of PPR vaccination and ensure their willingness to invest in vaccine administration.
Encourage adherence to instructions provided by animal health professionals regarding vaccine administration.
Provide training and certification to animal health professionals in accordance with national regulatory standards to ensure proficient vaccine administration.
Ensure vaccine quality meets national or regional standards to achieving good immunity of herds
Calculate the required quantity of products needed for your project based on an initial cost ranging from 0.3-0.5 USD per animal. Consider additional expenses such as delivery costs, import clearance, and duties, particularly if the technology is sourced from other countries.

A team of trainers can offer support and training during the installation phase of the project. Budget for training and post-training support for utilizing the technology effectively.

Consider collaborating with agricultural development institutes to facilitate the implementation of the technology within your country.

Cost: $$$ 0.3—1.0 USD

Vaccine dose cost per animal

ROI: $$$

IP

Open source / open access

Scaling Readiness describes how complete a technology’s development is and its ability to be scaled. It produces a score that measures a technology’s readiness along two axes: the level of maturity of the idea itself, and the level to which the technology has been used so far.

Each axis goes from 0 to 9 where 9 is the “ready-to-scale” status. For each technology profile in the e-catalogs we have documented the scaling readiness status from evidence given by the technology providers. The e-catalogs only showcase technologies for which the scaling readiness score is at least 8 for maturity of the idea and 7 for the level of use.

The graph below represents visually the scaling readiness status for this technology, you can see the label of each level by hovering your mouse cursor on the number.

Scaling readiness score of this technology

Maturity of the idea 8 out of 9

Uncontrolled environment: tested

Level of use 7 out of 9

Common use by projects NOT connected to technology provider

Maturity of the idea										Level of use
9
8
7
6
5
4
3
2
1
	1	2	3	4	5	6	7	8	9

Countries with a green colour: Tested & adopted
Countries with a bright green colour: Adopted
Countries with a yellow colour: Tested
Countries with a blue colour: Testing ongoing

Countries where the technology is being tested or has been tested and adopted
Country	Testing ongoing	Tested	Adopted
Mali	–No ongoing testing	Tested	Adopted

This technology can be used in the colored agro-ecological zones. Any zones shown in white are not suitable for this technology.

Agro-ecological zones where this technology can be used
AEZ	Subtropic - warm	Subtropic - cool	Tropic - warm	Tropic - cool
Arid
Semiarid
Subhumid
Humid

Source: HarvestChoice/IFPRI 2009

The United Nations Sustainable Development Goals that are applicable to this technology.

Goal 1: no poverty

Goal 2: zero hunger

Goal 3: good health and well-being

Goal 8: decent work and economic growth

Goal 9: industry, innovation and infrastructure

Goal 12: responsible production and consumption

Goal 13: climate action

Report outbreaks of PPR to national veterinary authorities as PPR is a notifiable disease.
Implement disease surveillance considering animal movement, farm quarantine, and identification of high-risk areas.
Source vaccines from reliable suppliers and ensure proper cold chain management.
Administer vaccines through trained and certified vaccinators, ensuring correct dosage.
Monitor vaccinated animals for signs of immunity and address any concerns promptly.

Last updated on 24 July 2025